Discordance for autoimmunity in monozygotic twins. are “identical” twins really identical?

Discordance of diabetic microangiopathy in identical twins.

In a pair of 19-year-old monozygotic twin girls, one developed insulin-dependent, ketosis-prone diabetes at the age of three and has required insulin for the past 16 years. Her identical twin has maintained normal oral and intravenous glucose tolerance with normal insulin release and glucagon suppression. An unequivocal hypertrophy of the muscle capillary basement membrane (1,800 +/- 148 A) was...

Monozygotic twins: identical in name only.

To the Editor: We found the study of clinical responses to opioids by Angst et al.1 to be an excellent first-of-its-kind study for distinguishing the contribution of heredity versus environment. Much work has been done using twins to separate heredity from environment and this addition to our literature is timely. Although the use of twins to separate nature from nurture is a long-established m...

Pre-eclampsia: discordance among identical twins.

Narcolepsy in identical twins.

Narcolepsy has been observed in chronic encephalitis, cerebral arteriosclerosis, brain tumour, and following trauma, but when these cases are excluded there remains a group without demonstrable brain pathology. The existence of this idiopathic group has been a controversial subject. Among the more impressive evidence is that suggesting a hereditary factor in idiopathic narcolepsy. To date this ...

[Sarcoidosis in identical twins].

M.R.C.S., F.R.S., and R. B. THOMPSON, M.D., M.R.C.P. .................................................... 605 Fulminating Staphylococcal Pneumonia Associated with Influenza Virus C C. S. DARKE, M.D., M.R.C.P., P. H. WATKINS, B.M., and J. E. M. WHITEHEAD, M.B., DiP.BaCt. ..... ......... 606 Protoveratrine A in Treatment of Hypertension IAN R. GRAY, M.D., M.R.C.P., and NEIL A. J. HAMER, M.B., M.R...